Serum Levels of Diphenylhydantoin and Phenobarbital in Epileptic Children Receiving Diphenylhydantoin, Phenobarbital and/or Mysoline
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چکیده
منابع مشابه
Simultaneous spectrophotometric determination of diphenylhydantoin and phenobarbital in biologic specimens.
A rapid, accurate method for determining diphenylhydantoinand phenobarbital in a single biologic sample is described. Separation of the two drugs after their initial chloroform extraction from the specimen is not required. After extraction, diphenylhydantoin is converted to benzophenone by pemanganate oxidation. Phenobarbital is determined by differential absorption between pH values of 12.0 an...
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The antiepileptic drugs diphenylhydantoin and phenobarbital were measured in serum by a new commercially available enzyme immunoassay procedure ("EMIT," Syva Corp.). The procedure requires less than 5 min and no more than 50 mul of serum per determination. It is simple; only four steps (pipetting and diluting with an automatic pipettor-dilutor) are required before spectrophotometry. Twenty repl...
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We describe a simple, sensitive determination of phenobarbital, diphenylhydantoin, carbamazepine, and primidone in serum, by use of gas-liquid chromatography with temperature programming. The methylated derivatives of these anticonvulsants are well resolved, as was 5-(p-methyl-phenyl)-5-phenylhydantoin, the internal standard. The proposed procedure requires only 0.20 ml of serum and can be done...
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We used a miniature centrifugal analyzer in a spectrophotometric rate-measurement mode to determine the anticonvulsant drugs phenobarbital and diphenylhydantoin in serum, by use of a modified enzyme immunoassay ("EMIT", Syva Corp.) We decreased reagent cost per determination by at least sixfold by means of microscale techniques. Also, the analysis rate is increased by measuring multiple samples...
متن کاملSimultaneous measurement of phenobarbital, diphenylhydantoin, and primidone in blood by high-pressure liquid chromatography.
We describe a sensitive, precise high-pressure liquid chromatographic method in which 5-(p-methylphenyl)-5-phenylhydantoin is used as the internal standard for simultaneous determination of diphenylhydantoin, phenobarbital, and primidone in whole blood and plasma. These anticonvulsant drugs are well separated from each other and from normal blood constituents in less than 10 min. The lower limi...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1974
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.112.169